Honest, evidence-based information on every major plant medicine — legal status by jurisdiction, therapeutic research findings, and how to access each legally and safely.
The active compound in "magic mushrooms." More clinical research than any other psychedelic — Johns Hopkins, NYU, Imperial College London. FDA Breakthrough Therapy designation for treatment-resistant depression and end-of-life distress. Oregon Measure 109 created the world's first licensed therapeutic framework in 2023. Colorado followed in 2025. 8,000+ legal facilitated sessions completed in Oregon alone as of early 2026.
Legal access: Oregon, Colorado (licensed facilitators) · Jamaica, Netherlands (full legal) · Mexico (decriminalised)
Retreat cost: $1,500–$8,000 · Session duration: 4–8 hours
A brew combining DMT-containing plants (usually Psychotria viridis) with MAO inhibitors (usually Banisteriopsis caapi). Sacred to Amazonian traditions for millennia. No Western clinical trials matching psilocybin's volume yet — but substantial observational research shows potential for depression, addiction, and PTSD. The MAOI component creates serious drug interaction risk that must be managed by experienced facilitators.
Legal access: Peru, Costa Rica, Brazil, Mexico (legally tolerated or ceremonial use) · Netherlands (legal)
Retreat cost: $2,000–$12,000 · Session duration: 6–10 hours
The only psychedelic-adjacent medicine with full FDA approval for depression (as esketamine/Spravato). Available via licensed ketamine clinics across the United States, Australia, and most Western countries. Rapid onset — many patients report relief within hours vs weeks for SSRIs. IV infusion, intramuscular, nasal spray, and oral lozenge routes available. The most accessible legal option for patients in restrictive jurisdictions.
Legal access: United States (nationwide, prescription), Australia (2023 TGA approval), UK, Canada
Treatment cost: $400–$800 per infusion · Series of 6 typical
From the Tabernanthe iboga shrub, used in West African Bwiti tradition. Extraordinary single-dose interruption of opioid withdrawal — the most dramatic addiction intervention in psychedelic research. FDA Phase 2 trials underway for opioid use disorder. The cardiac risk profile (QTc prolongation) is real and requires ECG screening, cardiac monitoring, and medically supervised settings. This is not recreational — it is serious medicine requiring serious protocols.
Legal access: Mexico, Portugal, South Africa, Gabon · Clinical trials in US and Canada
Retreat cost: $5,000–$15,000 (medical setting required)
MAPS-sponsored Phase 3 trials for PTSD showed 67% of participants no longer met PTSD diagnostic criteria after MDMA-assisted therapy — a landmark finding. The FDA rejected the initial approval application in 2024 citing data concerns. Re-submission and further trial data are expected. Currently only accessible via clinical trials in the US. Some retreat centres in Jamaica and the Netherlands offer MDMA-assisted work under legal local frameworks.
Legal access: Jamaica, Netherlands · US clinical trials only at this time
Therapy cost: $3,000–$10,000 · Typically 2–3 sessions
Secretion from the giant monkey frog (Phyllomedusa bicolor). Not a psychedelic — produces intense physical purging rather than visionary experience. Used in Amazonian tradition for "clearing" and building resistance. No clinical trial evidence base. Several deaths have occurred — all in contexts with cardiovascular conditions, too-large doses, or water intoxication. Not appropriate for most people. We list it for completeness but recommend extreme caution and thorough screening.
Legal in most countries but requires experienced practitioners and thorough health screening
Session cost: $200–$600 · Duration: 30–60 minutes
| Medicine | USA | Australia | UK | Canada | Legal Retreat Access |
|---|---|---|---|---|---|
| Psilocybin | OR + CO legal | Illegal (Schedule 9) | Illegal (Class A) | Trials only | Oregon, Colorado, Jamaica, Netherlands, Mexico |
| Ayahuasca | Illegal federal | Illegal | Illegal | Illegal | Peru, Costa Rica, Brazil, Netherlands |
| Ketamine | Legal nationwide | TGA approved 2023 | Prescription | Legal | Clinics in all 4 countries |
| Ibogaine | Schedule I federal | Illegal | Class A | Trials only | Mexico, Portugal, South Africa |
| MDMA | Trials only | Trials only | Trials only | Trials only | Jamaica, Netherlands only |
Tell us your goals, location, and medicine preference. We match you with verified retreat centres operating in legal jurisdictions.
Find My Retreat →